硫化氢和同型半胱氨酸在动脉粥样硬化病变中的研究现状.pdf

第27卷第6期
川北医学院学报
Vo. 27 No 6
2012年12月
JOURNAL OF NORTH SICHUAN MEDICAL COLLEGE
Dec,2012
doi:10.3969/j.isn.1005-3697.2012.06.007
?药学研究专题?
硫化氢和同型半胱氨酸在动脉粥样硬化病变中的
研究现状
刘会娟,周春阳
(川北医学院药学院,川北医学院药物研究所,四川南充637007
【摘要】动脉粥样硬化( atherosclerosis,AS)性病变是目前世界上心血管疾病的发生率与死亡率高的首位原因,严重危害人
们的生命健康安全。动脉粥样硬化主要累及大中动脉,是一种慢性复杂的累进型病理过称。高同型半胱氨酸血症( Hyperho-
mocystelnemia,HHcy)是动脉粥样硬化形成的独立危险因子,它可以通过转硫基作用等转化成硫化氢,但是其致病机制尚未完
全闸明。近年来,硫化氢( hydrogen sulfide,H2S)因其在心血管健康和内稳态调节平衡方面的诸多积极性作用而受到重要关
注。新近研究发现H2S在动脉粥样硬化病变过程中发挥重要作用。AS的发生发展与同型半胱氨酸( homocysteine,Hey)和
H2S存在一定的内在联系,本文拟对此方面的研究和认识作一综述。
【关键词】同型半胱氨酸;硫化氢;动脉粥样硬化;胱硫醚-β-合成酶;胱硫瞇-γ-袈解酶
文章编号】1005-3697(2012)06-0547-05【中图分类号】R543【文献标识码)A
Hydrogen sulfide and homocysteine atherosclerotic lesions in the current
status
LIU Hui-juan, ZHOU Chun-yang
(School of Pharmacy, Institute of Materia Medica, orth Sichuan Medical College, Nanchong 637007, Sichuan, China)
Abstract] Atherosclerotic lesions are the primary cardiovascular disease causing the highest rates of mortality resulting in serious
harm to peoples health and safety of life. Atherosclerosis is a chronic, complex, and progressive pathological process in large and me
dium sized arteries. Hyperhomocysteinemia has been recognized as an independent risk factor for atherosclerosis, which is converted to
hydrogen sulfide (H S )through the transsulfuration pathway. Controversy still remains though about its pathogenesis. H, S has attrac-
ted considerable attention in recent years for many of its positive effeets on vascular health and homeostasis. New research found H, S in
the atherosclerotic lesions play an important role in the process as happened with Hey and H2 S, which have certain developmental inter
nal relations. This paper reviews the research and understanding of these hydrogen sulfide processes
I Key words Homocysteinemia Hydrogen sulfide; Atherosclerosis; Cystathionine-8-synthase; Cystathionine-y-lyase
动脉粥样硬化( atherosclerosis,AS)性病变是目局部血栓形成(称为粥样硬化-血栓形成, atheroscle
前世界上心血管疾病的发生率与死亡率高的首位原 rosis- thrombosis)。到目前为止,AS的发病机制尚未
因,严重危害人们的生命健康安全。动脉粥样硬化最后阐明。学说很多,如脂质浸润学说、平滑肌突变
的特点是受累动脉的病变从内膜开始,先后有多种学说、炎症学说、内皮损伤学说、单核-巨噬细胞作用
病变合并存在,包括局部有脂质和复合糖类积聚、纤学说等
维组织增生和钙质沉着形成斑块,并有动脉中层的
大量流行病学调査显示高同型半胱氨酸血症
逐渐退变,继发性病变尚有斑块内出血、斑块破裂及( hyperhomocysteinemia,HHcy)与外周血管、脑血管
基金项目:四川省科技厅(05SC1862);四川省教育斤(11ZA193)
收稿日期:2012-10-06
作者简介:刘会娟(1986-),女,陕西宝鸡人,硕士研究生,主要从事心血管基础与临床药理学方面的研究
△通讯作者:周春阳,E~mail: chunyangzhou@ hotmail.eom
网络出版时间:2012-11-1217:12
网络出版地址:hte://w.cnki.net/kems/ detail/S1.1254.R.2012111.171.017.html