年轻宫颈鳞癌组织中c-Myc和COX-2相关性及与血管生成的关系.pdf

现代肿瘤医学2014年3月第22卷第3期 MODERN ONCOLOGY,Mar.2014,VOL.22,NO.03
年轻宫颈鱗癌组织中c-Mye和COX-2相关性及与血管生成的关系
王雅楠,李丽,吴士茜,孙冬霞,孔?平,魏
The expression and significance of C-myc and COX-2 in cervix neoplasms of young
Women
Wang Yanan, Li Li, Wu Shiqian, Sun Dongxia, Kong Weiping ,Wei Lan
Hand ee H e H e H He and 0,,,,,,,,, n
Abstract) Objective: To determine the expression of COX-2 and c-myc in cervix neoplasms, CIN and SCC a
mong young women under 35 and the research of MVD, to discuss the relationship between COX-2 and c-mye in
SCC. Methods: To detect the expressions of COX-2, C-myc and micro vessel density(MVD )labeled by CD43 in
40 cases in CC, 31 cases of CIN and 10 cases of NCE by immunohistochemistry S-P. And analyze the relationship
with histological grade, pathological type, axillary lymph node metastasis. Results: The positive expression rate of c
Mye in SCC was 62. 5%(25/40 ) which was significantly higher than that in CIN and NCE(P<0.01), the expression
of c-myc was located with myometrial invasion and lymph node metastasis, but it was unrelated with the stas
(P <0.01). The expression rate of COX-2 in SCC was 67.5(27/40), which was significantly higher than that n
CIN and NCE ( P<0.01), the expression of COX-2 was located with the stage of SCC and lymph node metastasis(P
<0.01). Expressions of them were positively correlated in SCC. Conclusion
COX-2 and C-MYC in SCC play an
important role in SCC, the high expressions of COX-2 and c-mye were meaningul
Key words ]cervical carcinoma;c-mye; COX-2; MVD; immunohistochemistry
Modern Oncology 2014, 22(03): 0625-0628
摘要目的:研究原趣基因(c-Mye)和环氧合旃-2(COX-2)在35岁以下宫颈上皮内瘤样病变(CIN)和
髙颈鏻癌(SCC)患者中的表达及与微血管密度(MVD的相关性,探讨c-Mye和COX-2在SCC发作发展中
的关系及与临床病理关系。方法:选择我院手术切除的SCC组织标本40例、CIN标本31例、正常官颈组织
(NCE)10例,采用免疫组化SP法檢测各组c-Myce和COX-2的表达情况及微血管密度(MVD)(CD34标
心)。并通过统计学方法分析ば表达情况及肿瘤分期、病理分型、淋结转移等之间的相互关系。结果:c
Mye在年轻SCC中的阳性表达率为62.5%(25/40),显著高于CIN组和NCE组(P<0.01),c-Mye在年
SCC中的表达与分化及淋巴结转移有关(P<0.01),与分期无关。年轻SCC组中COX-2阳性表达率为
67.5%(27/40),显著高于CIN组和NCE组(P<0.01),COX-2的表达与SC的分期及淋巴结转移有相关性
(P<0.01)。相关性分析发现两者在SCC组织中表达早正相关,两者在颈癌血管生成中可能只有协同作
用。结论:c-Myc和COX-2在轻SCC发生、发展中起重要作用,c-Myc和COX-2上调表达可作为SCC
后的判断指标
【关键词】子官内膜肿瘤;c-Mye蚩白;COX-2蛋白;MVD;免疫组织化学
【中图分类号)R737.33【文献标识码】ADOI:10.3969/isn.1672-4992.2014.03.43
【文章编号1672-4992-(2014)03-0625-04
出颈鱗癌(SCC)是危害女性健,仅次于乳腺癌的第二SCC得以甲期发现和治疗,貝发病率和死亡率有所下降,随
大肿瘤,虽然近40年由于颈细胞学筛查的当遍应用,使着当今社会“性”开放程度加剧,发现SC发病午龄有年轻
化趋势,严重威胁年轮女性的健康,刈年轮化SCC应引起社
收稿H期】2013-08-20
公警惕。针对SC年轻患者,只术后复发、转移等仍是治疒
【修回日期】2013-09-10
的难题,随着分子生物学的发展,人们认识到肿瘤的发展、转
作者単位】'邯郸市妇幼保健院,河北邯郸056001
移与基因的?常有着密切的关系,可以认为舯瘤就是基因的
2邯郎市中心医院,河北邯郸056001
疾病,本研究采用免疫组化SP法检测40例SCC年轻组中c
【作者简介】主雅楠(1966-),女,河北邯郸人,主治医师,主要从
Myc和COX-2表达及MVD值情况,分析并探讨二者在
事如科临床工作
其发生、发展和转移中的作用,为临床治疗提供帮助
通讯作者」孙冬霞(1977-),女,河北邯郭人,硕上,副主任医师,
资料与方法
主要从事肿瘤诊断研究工作。E-mail: sundongxial20
1.1资料
0163.com