广送堂2016年1月第38卷第1期
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阿托伐他汀钙强化治泞对动脉粥样硬化
脑梗死患者血脂水平及颂动脉斑块的影响
吴霖浦
(广西桂林市人民医院神经内科,桂林市541002,E-mail:e2286@163.com
【摘要】目的探讨阿托伐他汀钙强化治疔对动脉粥样硬化脑梗死患者血脂水平及颈动脉斑块的影响。方法选择
动脉粥样硬化脑梗死患者92例,以随机数字表法分为观察组和对照组各46例。两组均给子饮食控制,对照组采用常规剂
量阿托伐他汀钙(10mg/d)治疗,观察组采用强化阿托伐他汀钙(40mg/d)治疗,观察治疗前后两组患者血脂情况以及颈动
脉斑块情况。结果治疗后两组TC、TG、LDL-C水平、斑块大小、班块厚度以及颈总动脉内膜-中层厚度(IMT)均低于治疗
前(P<0.05),且观察组各项指标显著低于对照组(P<0.05);治疗后两组HDI-C水平升高(P<0.05),且观察组较对照组
明显增高(P<0.05)。结论强化剂量阿托伐他汀可有效改善动脉粥样硬化脑楩死患者血脂异常和颈动脉斑块的情况。
【关键词】动脉粥样硬化;脑梗死;阿托伐他汀钙;强化治疗;血脂;颈动脉斑块
中图分类号】R743.33【文献标识码
【文章编号】0253-4304(2016)01-0071-03
DOI:10.11675/j.issn.0253-4304.2016.01.22
Eifect of intensive treatment with atorvastatin calcium on blood lipid level and
carotid artery plaque in patients with atherosclerotic cerebral infarction
Department of urology, the Peoples Hospital of Guilin City, Guilin 541002, China
I Abstract Objective T explore the effect of intensive treatment with ator astatin calcium on blood lipid level and carotid artery
plaque in patients with atherosclerotic cerebral infarction. Methods A total of 2 patients with atherosclerotic cerebral infarction were
enrolled and were divided into observation group(n=46)and control group(n=46 )by random number table. The diet control was
performed in both groups. And control group was administered atorvastatin calcium with normal dose(10 mg/d), while observation group
received intensive treatment with atorvastatin calcium(40 mg/d). The blood lipid level and carotid artery plaque were observed in both
groups before and after treatment. Results After treatment, the levels of TC, TG and LDL-C were significantly lower, and the plaque size
plaque thickness and carotid artery intima-media thickness(IM were less in both gu(P<0.5), and those indicators in the ob rvation
group improved more significantly compared to the indicators in the control group(P<0.05). The level of HLD-C increased in both groups
after treatment(P <0. 05), and the level in the observation group was significantly higher than that in the control group(P<0.05
Conclusion Atorvastatin calcium with intensive dose can improve effectively the abnormity of blood lipid and carotid artery plaque in
patients with atherosclerotic cerebral infaretion
Key words Atherosclerosis, Cerebral infarction, Atorvastatin calcium, Intensive treatment, Blood lipid, Carotid artery plaque
动脉粥样硬化性脑梗死是由于脑部动脉内膜处脂切相关的低密度脂蛋白胆固醇(LDL-C)。此外
他汀类质积聚并形成血栓,导致脑部血管管壁增厚变硬,最终药物还有升高高密度脂貨白胆固醇(HDL-C)的作用。
弹性消失,管腔直径变窄甚至阻塞,使患者脑部供血不强化剂量的他汀类药物可阻止动脉粥样硬化进一步恶
足,引起供血区域脑组织缺血性坏死。该疾病可能会导化甚至缓解该症状,改善动脉粥样硬化脑梗死患者的预
致患者出现同侧肢体瘫痪、语言能力丧失等后遗症,对后。本文对比强化阿托伐他汀方案与常规剂量他
患者预后影响较大。对于动脉粥样硬化性脑梗死,应采汀类在动脉粥样硬化性脑梗死患者中的治疗效果,现报
取相应的治疗以使患者早日恢复-?,并减轻疾病给家告如下
改辞血脂的常状混。日前在临床上采用最多的降脂1资料与方法
类药物是他汀类药物,其可以通过竞争性抑制内源性胆1.1临床资料选择2012年4月至2014年4月我院
固醇合成限速酶还原晦,使体内胆固醇合成减少,从而的收治动脉粥样硬化性脑梗死患者92例,年岭50~74
可有效降低血清中的胆固醇,尤其是与动脉粥样硬化密(67.5±1.9)岁,其中男50例,女42例。发病至就诊时
作者简介:吴霖浦(1969~),男,硕士,副主任医师,研究方向:脑血管疾病。
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